Radioimmunotherapy of Fibroblast Activation Protein Positive Tumors by Rapidly Internalizing Antibodies
نویسندگان
چکیده
منابع مشابه
Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies.
PURPOSE Fibroblast activation protein (FAP) is a serine protease that has emerged as a promising target for cancer therapy, either by direct abrogation of its proinvasive activity or by specific targeting of FAP-expressing cells with cytotoxic immunoconjugates. We aimed to select novel human-mouse cross-reactive antibodies and to test suitability for tumor therapy as radioimmunoconjugates in a ...
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1 IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France; INSERM, U896, Montpellier, F-34298, France; Université Montpellier1, Montpellier, F34298, France; CRLC Val d’Aurelle Paul Lamarque, Montpellier, F-34298, France; 2 CRLC Val d’Aurelle-Paul Lamarque, F-34298 Montpellier, France; 3 Service de Médecine Nucléaire, CHU de Nîmes, Nîmes F-30029, France; 4 Direct...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2012
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-12-0644